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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SH2B3 All Species: 13.94
Human Site: Y74 Identified Species: 34.07
UniProt: Q9UQQ2 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQQ2 NP_005466.1 575 63225 Y74 F T D L F Q R Y F C R E V R D
Chimpanzee Pan troglodytes XP_001145612 575 63234 Y74 F T D L F Q R Y F C R E V R D
Rhesus Macaque Macaca mulatta XP_001108790 570 62567 Y74 F T D L F Q R Y F C R E V R D
Dog Lupus familis XP_546938 639 67478 F67 S R H F A A N F L D V F G E E
Cat Felis silvestris
Mouse Mus musculus O09039 548 60469 F67 S L Q F A E L F Q R H F C R E
Rat Rattus norvegicus P50745 368 40414
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506291 650 72002 Y119 F T D L F Q Q Y F R H E V R E
Chicken Gallus gallus XP_001234467 640 70256 F75 S V E V S R V F V S D S P T N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001338493 596 67866 H70 F S A L F Q H H F S C E V A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624395 579 64607 S89 E S A R L N L S H H D F L K K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 96.5 34.2 N.A. 72.6 30.2 N.A. 63 33.1 N.A. 44.9 N.A. N.A. 30.5 N.A. N.A.
Protein Similarity: 100 98.9 96.8 45 N.A. 78.9 38.4 N.A. 68.9 45.7 N.A. 55.8 N.A. N.A. 46.4 N.A. N.A.
P-Site Identity: 100 100 100 0 N.A. 6.6 0 N.A. 73.3 0 N.A. 46.6 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 100 100 100 13.3 N.A. 26.6 0 N.A. 86.6 33.3 N.A. 60 N.A. N.A. 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 20 0 20 10 0 0 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 30 10 0 10 0 0 % C
% Asp: 0 0 40 0 0 0 0 0 0 10 20 0 0 0 30 % D
% Glu: 10 0 10 0 0 10 0 0 0 0 0 50 0 10 30 % E
% Phe: 50 0 0 20 50 0 0 30 50 0 0 30 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % G
% His: 0 0 10 0 0 0 10 10 10 10 20 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 20 % K
% Leu: 0 10 0 50 10 0 20 0 10 0 0 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 10 0 0 0 0 0 0 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % P
% Gln: 0 0 10 0 0 50 10 0 10 0 0 0 0 0 0 % Q
% Arg: 0 10 0 10 0 10 30 0 0 20 30 0 0 50 0 % R
% Ser: 30 20 0 0 10 0 0 10 0 20 0 10 0 0 0 % S
% Thr: 0 40 0 0 0 0 0 0 0 0 0 0 0 10 0 % T
% Val: 0 10 0 10 0 0 10 0 10 0 10 0 50 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 40 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _